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Publications

Journal Article Review Epublish

PubMed: 39781425 DOI: 10.1096/fba.2024-00166

Copper homeostasis; A rapier between mycobacteria and macrophages.

FASEB Bioadv 7(1):e1484

Authors: Di Hu, Zisha Yang, Jun-Ai Zhang, Ganbin Liu, Jiang Pi, Junfa Xu, Yan Wang, Yi Zhao

Affiliations

  • Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics The First Dongguan Affiliated Hospital, Guangdong Medical University Dongguan Guangdong China. Institute of Laboratory Medicine, School of Medical Technology Guangdong Medical University Dongguan Guangdong China.
  • Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics The First Dongguan Affiliated Hospital, Guangdong Medical University Dongguan Guangdong China.
  • Department of Respiration Dongguan 6th Hospital Dongguan Guangdong China.
  • Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics The First Dongguan Affiliated Hospital, Guangdong Medical University Dongguan Guangdong China. Microbiology and Immunology Department Guangdong Medical University Dongguan Guangdong China.
  • Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics The First Dongguan Affiliated Hospital, Guangdong Medical University Dongguan Guangdong China. Institute of Laboratory Medicine, School of Medical Technology Guangdong Medical University Dongguan Guangdong China. Microbiology and Immunology Department Guangdong Medical University Dongguan Guangdong China.

Abstract

Copper is a vital trace element crucial for mediating interactions between and macrophages. Within these immune cells, copper modulates oxidative stress responses and signaling pathways, enhancing macrophage immune functions and facilitating clearance. Conversely, copper may promote escape from macrophages through various mechanisms: inhibiting macrophage activity, diminishing phagocytic and bactericidal capacities, and supporting survival and proliferation. This paradox has intensified research focus on the regulatory role of copper in immune cell-pathogen interactions. Interactions among metal ions can affect concentration, distribution, and activity within an organism. In this review, we have elucidated the role of copper in these interactions, focusing on the mechanisms by which this metal influences both the immune defense mechanisms of macrophages and the survival strategies of . The findings suggest that manipulating copper levels could enhance macrophage bactericidal functions and potentially limit resistance. Therefore, elucidating the regulatory role of copper is pivotal for advancing our understanding of metal homeostasis in immune cell-pathogen dynamics and TB pathogenesis. Furthermore, we recommend further investigation into the role of copper in TB pathogenesis to advance tuberculosis diagnosis and treatment and gain comprehensive insights into metal homeostasis in infectious disease contexts.

MeSH

Cells, Mycobacterium, Homeostasis, Macrophages, Mycobacterium Tuberculosis, Immune Evasion

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