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Publications

Journal Article Ppublish

PubMed: 39828609 DOI: 10.1002/adhm.202403607

Liquid Crystalline Networks Hamper the Malignancy of Cancer Cells.

Adv Healthc Mater 14(7):e2403607

Authors: Daniele Martella, Ignazia Tusa, Alessandro Tubita, Alessia Negri, Marco Turriani, Marta Rojas-Rodríguez, Martina Salzano de Luna, Alessio Menconi, Camilla Parmeggiani, Elisabetta Rovida

Affiliations

  • Department of Chemistry "Ugo Schiff", University of Florence, via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy.
  • European Laboratory for Non Linear Spectroscopy (LENS), via N. Carrara 1, Sesto Fiorentino, 50019, Italy.
  • Department of Clinical and Experimental Biomedical Sciences, University of Florence, Viale G.B. Morgagni, 50, Florence, 50134, Italy.
  • Department of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II, Piazzale V. Tecchio, 80, Napoli, 80125, Italy.

Abstract

Mimicking compositions and structures of extracellular matrix is widely studied to create in vitro tumor models, to deepen the understanding of the pathogenesis of the different types of cancer, and to identify new therapies. On the other hand, the use of synthetic materials to modulate cancer cell biology and, possibly, to reduce the malignancy of cancer cells through their exploitation is far less explored. Here, the study evaluates the effects of Liquid Crystalline Networks (LCNs) based scaffolds on the growth of A375 metastatic melanoma cells. Interestingly, cells grown on such materials show reduced cell proliferation and colony-forming capacity with respect to those cultivated on standard plates. These effects are associated with a higher percentage of senescent cells and a shift to a more epithelial phenotype, pointing to the occurrence of a mesenchymal to epithelial transition. All these biological outcomes are affected by the amount of crosslinker in the material and have been induced only thanks to the interactions with the polymeric substrate without the need of further chemical (e.g., specific growth factor) or physical (e.g., irradiation) stimuli, opening to the possible development of anti-cancer coatings.

MeSH

Cells, Growth, Neoplasms, Cellular Senescence

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