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Publications

Journal Article Review Ppublish 3 citations

PubMed: 39853950 DOI: 10.1111/jipb.13837

Regulatory and retrograde signaling networks in the chlorophyll biosynthetic pathway.

J Integr Plant Biol 67(4):887-911

Authors: Yuhong Li, Tianjun Cao, Yunling Guo, Bernhard Grimm, Xiaobo Li, Deqiang Duanmu, Rongcheng Lin

Affiliations

  • Key Laboratory of Photobiology, Institute of Botany, the Chinese Academy of Sciences, Beijing, 100093, China.
  • School of Life Sciences, Westlake University, Hangzhou, 310030, China. Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, 310024, China.
  • State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.
  • Institute of Biology/Plant Physiology, Humboldt-Universität zu Berlin, Berlin, 10115, Germany.
  • The Zhongzhou Laboratory for Integrative Biology, State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, 475004, China.
  • Key Laboratory of Photobiology, Institute of Botany, the Chinese Academy of Sciences, Beijing, 100093, China. Institute of Biotechnology, Xianghu Laboratory, Hangzhou, 311231, China.

Abstract

Plants, algae and photosynthetic bacteria convert light into chemical energy by means of photosynthesis, thus providing food and energy for most organisms on Earth. Photosynthetic pigments, including chlorophylls (Chls) and carotenoids, are essential components that absorb the light energy necessary to drive electron transport in photosynthesis. The biosynthesis of Chl shares several steps in common with the biosynthesis of other tetrapyrroles, including siroheme, heme and phycobilins. Given that many tetrapyrrole precursors possess photo-oxidative properties that are deleterious to macromolecules and can lead to cell death, tetrapyrrole biosynthesis (TBS) requires stringent regulation under various developmental and environmental conditions. Thanks to decades of research on model plants and algae, we now have a deeper understanding of the regulatory mechanisms that underlie Chl synthesis, including (i) the many factors that control the activity and stability of TBS enzymes, (ii) the transcriptional and post-translational regulation of the TBS pathway, and (iii) the complex roles of tetrapyrrole-mediated retrograde signaling from chloroplasts to the cytoplasm and the nucleus. Based on these new findings, Chls and their derivatives will find broad applications in synthetic biology and agriculture in the future.

MeSH

Chlorophyll, Heme, Botany, Photosynthesis, Tetrapyrroles

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