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Journal Article Epublish 7 citations

PubMed: 40358254 DOI: 10.3390/nano15090637

Antimicrobial Coatings Based on Hybrid Iron Oxide Nanoparticles.

Nanomaterials (Basel) 15(9)

Authors: Doina-Antonia Mercan, Dana-Ionela Tudorache Trifa, Adelina-Gabriela Niculescu, Laurenţiu Mogoantă, George Dan Mogoşanu, Alexandra Cătălina Bîrcă, Bogdan Ștefan Vasile, Ariana Hudiță, Ionela Cristina Voinea, Miruna S Stan, Tony Hadibarata, Dan Eduard Mihaiescu, Alexandru Mihai Grumezescu, Adina Alberts

Affiliations

  • Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
  • Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.
  • Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania.
  • Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania.
  • Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania.
  • Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania.
  • Research Center for Advanced Materials, Products and Processes, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania.
  • National Research Center for Micro and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania.
  • Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei Street, 050095 Bucharest, Romania.
  • Environmental Engineering Program, Faculty of Engineering and Science, Curtin University Malaysia, CDT 250, Miri 98009, Malaysia.
  • Department of Organic Chemistry, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
  • Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Abstract

This study presents the preparation of hybrid iron oxide nanocomposites through a two-step process combining microfluidic-assisted synthesis and post-synthetic surface modification. FeO nanoparticles were synthesized and simultaneously functionalized with salicylic acid using a three-dimensional vortex-type microfluidic chip, enabling rapid and uniform particle formation. The resulting FeO/SA nanostructures were further modified with either silver or copper oxide to form iron oxide nanocomposites with enhanced antimicrobial functionality. These nanocomposites were subsequently integrated into silica aerogel matrices using a dip-coating approach to improve surface dispersion, structural stability, and biocompatibility. The structural and morphological properties of the samples were investigated using XRD, FT-IR, TEM with SAED analysis, and Raman microscopy. In vitro cytotoxicity and antimicrobial assays demonstrated that FeO/SA-Ag and FeO/SA-CuO exhibit potent antibacterial activity and cell type-dependent biocompatibility. In vivo biodistribution studies showed no accumulation in major organs and selective clearance via the spleen, validating the systemic safety of the platform. These findings highlight the potential of the synthesized nanocomposites as biocompatible, antimicrobial coatings for advanced biomedical surfaces.

MeSH

Nanoparticles, Microfluidics, Nanocomposites

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