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Publications

Journal Article Research Support, Non-U.S. Gov't Ppublish

PubMed: 40490419 DOI: 10.1111/dom.16515

Association of time in tight range and 1,5-anhydroglucitol in type 2 diabetes.

Diabetes Obes Metab 27(9):4772-4781

Authors: Hang Su, Jiaying Ni, Danfeng Peng, Xingxing He, Wei Lu, Wei Zhu, Yufei Wang, Xiaojing Ma, Jingyi Lu, Jian Zhou

Affiliations

  • Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
  • Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
  • Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China. Department of Emergency Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

AIMS

Among the novel metrics derived from continuous glucose monitoring (CGM), time in tight range (TITR) has gained increasing attention. Our study aimed to investigate the relationship between 1,5-anhydroglucitol (1,5-AG) and TITR in patients with type 2 diabetes.

MATERIALS AND METHODS

This cross-sectional study included 1531 moderately controlled patients with type 2 diabetes on a stable treatment regimen. TITR and time in range (TIR) were measured with CGM. Spearman correlation analysis was used to assess the relationship between serum 1,5-AG and TITR, and the predictive efficacy of serum 1,5-AG for identifying TITR > 50% was evaluated by the receiver operating characteristic curves.

RESULTS

The median levels of serum 1,5-AG and glycated haemoglobin A1c (HbA1c) in the total population were 7.4 (4.4, 12.1) μg/mL and 7.0% (6.4%, 7.5%), respectively. The median TITR was 52.0% (32.0%, 69.0%). Spearman correlation analysis showed that serum 1,5-AG was positively correlated with TITR (p < 0.001). The optimal serum 1,5-AG cut-off for TITR >50% was 8.0 μg/mL, with an area under the curve (AUC) of 0.693 (0.667, 0.719). Serum 1,5-AG combined with fasting glucose or 2-hour postprandial glucose further improved the predictive power for identifying TITR > 50% (both p < 0.001). Across all subgroups, serum 1,5-AG showed acceptable predictive accuracy for TITR > 50% (AUCs around 0.700).

CONCLUSIONS

Serum 1,5-AG was significantly correlated with TITR in patients with type 2 diabetes, with 8.0 μg/mL emerging as a potential cut-off for identifying TITR > 50%.

MeSH

Diabetes Mellitus, Serum, Diabetes Mellitus, Type 2, Continuous Glucose Monitoring

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