Journal Article Ppublish
PubMed: 40501109 DOI: 10.1002/alz.70315
Influence of ethnicity on the diagnostic accuracy of plasma p-tau217 for the identification of Alzheimer's disease: A consecutive mixed memory clinic cohort study.
Alzheimers Dement 21(6):e70315
Authors: Daniel Kjaergaard, T Rune Nielsen, Erik Stomrud, Sebastian Palmqvist, Divya Bali, Anna Orduña Dolado, Shorena Janelidze, Oskar Hansson, Gunhild Waldemar, Anja Hviid Simonsen
Affiliations
- Danish Dementia Research Centre, Department of Neurology, Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
- Danish Dementia Research Centre, Department of Neurology, Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden. Memory Clinic, Skåne University Hospital, Malmö, Sweden.
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
- Danish Dementia Research Centre, Department of Neurology, Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Abstract
INTRODUCTION
Blood-based biomarkers have demonstrated high accuracy for identifying Alzheimer's disease (AD) pathology. However, the lack of representative cohorts creates a knowledge gap regarding their real-world applicability. We examined the influence of ethnicity on the diagnostic accuracy of plasma tau phosphorylated at threonine 217 (p-tau217) in identifying AD.
METHODS
A total of 1170 mixed memory clinic patients originating from 91 different countries were included. Cerebrospinal fluid or amyloid positron emission tomography supplemented the diagnostic evaluation for 539 patients. Plasma was analyzed for p-tau217.
RESULTS
Plasma p-tau217 concentrations did not differ between ethnic groups, and there was no influence of ethnicity on the diagnostic accuracy of plasma p-tau217. Plasma p-tau217 demonstrated strong discriminative ability for AD and AD-pathology in our ethnically diverse cohort.
DISCUSSION
Our study suggests that ethnicity does not influence the diagnostic accuracy of plasma p-tau217. Nonetheless, medical conditions influencing plasma biomarkers may disproportionally affect minoritized groups because of social determinants of health.
HIGHLIGHTS
Plasma tau phosphorylated at threonine 217 (p-tau217) was highly accurate in the identification of Alzheimer's disease. Geographic origin did not influence the precision of plasma p-tau217. Kidney function may influence p-tau217 concentrations. Representative inclusion in studies and trials should be a priority.
MeSH
Dementia, Alzheimer Disease, Pathology, Cohort Studies, Biomarkers, Threonine, Memory, Plasma