Journal Article Review Comparative Study Ppublish
PubMed: 40536322 DOI: 10.1002/advs.202417657
Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer.
Adv Sci (Weinh) 12(30):e17657
Authors: Deepak S Chauhan, Kun Shao, Roopa Hebbandi Nanjundappa, Daniel-Jiajun Yu, Marianne Stanford, Huile Gao, Channakeshava Sokke Umeshappa
Affiliations
- Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
- Department of Pediatrics, IWK Research Center, Halifax, NS, B3K 6R8, Canada.
- State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116023, China.
- Faculty of Pharmacy, Universite de Montreal, Montreal, QC, H3T 1J4, Canada.
- Key Laboratory of Drug-Targeting and Drug Delivery System, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Abstract
Photo-responsive/activable nanomedicine-driven therapies have emerged as a transformative approach to effectively target and eliminate tumors across different types of solid cancers. When synergistically combined with immunomodulators, these therapies significantly enhance anti-cancer efficacy. This comprehensive review examines the current advancements in photo-responsive/activable immunomodulator-loaded nanomedicines (PINs), providing a detailed analysis of their preclinical development, clinical translation, and associated research funding. The diverse PINs are systematically categorized, innovative design strategies are explored, and the underlying photo-responsive/activable and immunomodulatory mechanisms are elucidated. By integrating clinical advancements with technical innovations and financial perspectives, this review bridges the translational gap, underscoring the immense potential of PINs to revolutionize cancer therapy. This comprehensive resource is indispensable for researchers striving to bring phototherapies to clinical fruition in the battle against cancer.
MeSH
Photochemotherapy, Nanomedicine, Biomedical Research, Neoplasms, Capital Financing, Photothermal Therapy, Immunotherapy, Phototherapy, Research, Therapeutics