Journal Article Review Ppublish 2 citations
PubMed: 40689767 DOI: 10.1096/fj.202500509RR
Exploring Therapeutic Targets From Spreading Patterns Against Respiratory Syncytial Virus.
FASEB J 39(14):e70858
Authors: Han Zhang, Zhao Zhang, Yixuan Yang, Jingjing Pei
Affiliations
- State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China. Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China.
Abstract
Human respiratory syncytial virus (RSV) is a pathogen that causes severe respiratory illness in humans, primarily infecting infants, young children, the elderly, and adults with chronic health conditions. Each year, approximately 3.6 million children under the age of 5 are hospitalized worldwide, with over 100 000 fatalities reported. Currently, available RSV vaccines and antiviral drugs have several limitations, including inadequate immune persistence, limited applicability to specific populations, strict timing of treatment, and the risk of adverse reactions. RSV spreads through three main infection modes: syncytia formation, receptor-dependent infection of free viral particles, and transmission via actin filaments. These modes of transmission are key pathways that contribute to viral spread and pathogenicity while exposing potential targets for prevention and treatment. This is a complex process involving multiple aspects that remain not fully understood. Here, we review the mechanisms by which RSV infects and spreads within the host and explore the role of host factors in these processes, aiming to provide a theoretical and practical basis for identifying potential antiviral targets.
MeSH
Respiratory Syncytial Viruses, Giant Cells, Viruses, Therapeutics, Antiviral Agents, Infections, Child