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Publications

Journal Article Ahead of print 24 citations

PubMed: 41208145 DOI: 10.1002/ejhf.70090

Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy.

Eur J Heart Fail

Authors: Gianluigi Savarese, Felix Lindberg, Antonio Cannata, Marianna Adamo, Giuseppe Ambrosio, Pietro Ameri, Markus S Anker, Magnus Bäck, Antoni Bayes-Genis, Tuvia Ben Gal, Frieder Braunschweig, Ovidiu Chioncel, Emilia D'Elia, Hassan El-Tamimi, Gerasimos Filippatos, Nicolas Girerd, Loreena Hill, Ewa Jankowska, Kamlesh Khunti, Basil S Lewis, Brenda Moura, Offer Amir, Stefania Paolillo, Massimo Piepoli, Abdulla Shehab, Maggie Simpson, Hadi Skouri, Davide Stolfo, Carlo Gabriele Tocchetti, Cristiana Vitale, Maurizio Volterrani, Stephan von Haehling, Sven Wassmann, Mehmet Birhan Yilmaz, Juan Carlos Kaski, Dobromir Dobrev, Marco Metra, Giuseppe M C Rosano

Affiliations

  • Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
  • Cardiology Department, King's College Hospital NHS Foundation Trust, London, UK.
  • Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
  • Center for Clinical and Translational Research - CERICLET, Department of Medicine, University of Perugia, Perugia, Italy.
  • Italian National Institute for Cardiovascular Research - INRC, Bologna, Italy.
  • Department of Internal Medicine, University of Genova, Genoa, Italy.
  • IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Department of Cardiology (CBF), German Heart Center Charité, BIH Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK) partner site Berlin, University Medicine Berlin FU and HU, Berlin, Germany.
  • Department of Cardiology, Heart and Vascular Center, Karolinska University Hospital, Stockholm, Sweden.
  • Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  • Université de Lorraine, INSERM, DCAC, Nancy, and CHRU Nancy, Vandoeuvre-lès-Nancy, Nancy, France.
  • Heart Institute, Hospital Universitari Germans Trias I Pujol, CIBERCV, Badalona, Spain.
  • Heart Failure Unit, Rabin Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  • Emergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu', University of Medicine Carol Davila, Bucharest, Romania.
  • Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo, Italy.
  • School of Medicine and Surgery, University of Milano Bicocca, Milan, Italy.
  • Mediclinic Parkview Hospital and Mohammad Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.
  • National and Kapodistrian University of Athens, School of Medicine, Department of Cardiology, Attikon University Hospital, Athens, Greece.
  • CHRU de Nancy, Centre d'Investigations Cliniques Plurithématique 1433, Inserm U1116, INSERM, Université de Lorraine, and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN Network, Nancy, France.
  • School of Nursing and Paramedic Science, Ulster University, Londonderry, UK.
  • Department of Translational Cardiology and Clinical Registries, Institute of Heart Diseases, Wrocław Medical University, Institute of Heart Diseases, University Hospital in Wrocław, Wroclaw, Poland.
  • Diabetes Research Centre, University of Leicester, Leicester, UK.
  • Lady Davis Carmel Medical Center and the Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
  • Armed Forces Hospital, Porto, Portugal.
  • Faculty of Medicine of University of Porto, Porto, Portugal.
  • Heart Institute, Hadassah Medical Center & Hebrew University, Jerusalem, Israel.
  • Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy.
  • Department of University Cardiology, IRCCS Policlinico San Donato, Milan, Italy.
  • Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
  • UAE University and Burjeel Royal Al Ain, Al Ain, UAE.
  • Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
  • Department of Cardiology, Balamand University Faculty of Medicine, Beirut, Lebanon.
  • Division of Cardiology, Internal Medicine department Sheikh Shakhbout Medical City, Abu Dhabi, UAE.
  • Cardiothoracic Department, Azienda Sanitaria Universitaria Friuli Centrale and University Hospital of Udine, Udine, Italy.
  • Cardio-Pulmonary Onco-Immunology, Department of Internal Medicine and Clinical Complexity, Department of Translational Medical Sciences (DISMET), Center for Basic and Clinical Immunology Research (CISI), Interdepartmental Center for Clinical and Translational Research (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy.
  • IRCCS San Raffaele Roma, Rome, Italy.
  • San Raffaele Open University of Rome, Rome, Italy.
  • Department of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany.
  • DZHK (German Center for Cardiovascular Research), partner site Lower Saxony, Göttingen, Germany.
  • Cardiology Pasing, Munich, and Faculty of Medicine, University of the Saarland, Homburg, Germany.
  • Department of Cardiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Türkiye.
  • Cardiovascular and Cell Sciences Research Institute at St George's, University of London, London, UK.
  • Faculty of Medicine, Institute of Pharmacology, University Duisburg-Essen, Essen, Germany.
  • Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montréal, QC, Canada.
  • Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
  • Department of Human Sciences and Promotion of Quality of Life, San Raffaele Open, University of Rome, Rome, Italy.

Abstract

Heart failure (HF) affects over 60 million individuals globally. Contemporary guideline-directed medical therapies (GDMT) reduce cardiovascular mortality and HF hospitalizations. However, medication non-adherence represents a critical barrier limiting real-world efficacy of GDMT. This scientific statement aims to provide a comprehensive framework for understanding, measuring, and addressing medication non-adherence in HF management across diverse healthcare settings. Addressing medication non-adherence requires systematic, multifaceted approaches targeting individual patient barriers while implementing system-level interventions. Polypills, digital monitoring platforms, enhanced patient education and empowerment, and multidisciplinary care models represent promising strategies to optimize therapeutic adherence and improve clinical outcomes in HF management.

MeSH

Heart Failure, Heart, Drug Therapy, Therapeutics