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Journal Article Ahead of print 1 citation

PubMed: 42299478 DOI: 10.1093/ejendo/lvag102

Mid-pregnancy serum chemerin levels predict persistence of postpartum hypertension in patients with polycystic ovary syndrome.

Eur J Endocrinol

Authors: Stefano Palomba, Giuseppe Seminara, Flavia Costanzi, Rossella Cannarella, Tiziana Russo, Martina Sarica, Fabrizio Signore, Donatella Caserta, Aldo E Calogero, Antonio Aversa

Affiliations

  • Unit of Obstetrics & Gynecology, Grande Ospedale Metropolitano "Bianco-Melacrino-Morelli" di Reggio Calabria, 89124 Reggio Calabria, Italy.
  • Department of Medical-Surgical Sciences and Translational Medicine, University "Sapienza" of Rome, 00185 Rome, Italy.
  • Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
  • Endocrinology Unit, "Renato Dulbecco" University Hospital, 88100 Catanzaro, Italy.
  • Unit of Gynecology, Sant'Andrea Hospital of Rome, 00189 Rome, Italy.
  • Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy.
  • Obstetrics and Gynecology Department, USL Roma 2, Sant'Eugenio Hospital, 00144 Rome, Italy.

Abstract

OBJECTIVE

Polycystic ovary syndrome (PCOS) is associated with a higher incidence of pregnancy-related hypertensive disorders (PHD), and an increased cardiometabolic risk. Chemerin, an adipokine involved in metabolic and inflammatory pathways, has been linked to both PCOS and PHD. This study was designed to test the hypothesis that mid-pregnancy maternal serum chemerin levels may predict persistent hypertension one year after delivery in women with PCOS and a history of PHD.

DESIGN

Longitudinal cohort study.

METHODS

Ninety-two patients with and without PCOS and previous PHD were studied 12 months after delivery. Serum chemerin concentrations were measured at 20 weeks of gestation. Logistic regression models were used to assess the association between chemerin and persistent hypertension. Receiver operating characteristic curve analysis evaluated predictive performance.

RESULTS

Women with persistent hypertension exhibited significantly higher chemerin levels compared with normotensive women (median 31.3 vs. 20.1 ng/mL; P = 0.0003). Chemerin concentrations resulted independently associated with persistent hypertension (adjusted odds ratio 6.66 per 10 ng/mL; 95% CI 2.21-20.07; P = 0.0007). Among women with PCOS, a higher chemerin threshold (∼32.3 ng/mL) provided a positive predictive value of 57.1% and a negative predictive value of 82.9%.

CONCLUSIONS

Mid-pregnancy chemerin levels independently predict persistent hypertension after delivery in patients with PCOS and prior PHD.

MeSH

Hypertension, Pregnancy, Serum, Ovary, Predictive Value Of Tests, Hormones, Polycystic Ovary Syndrome, Adipokines, Postpartum Period