Brief Summary

Pressure support ventilation (PSV) is used to assist the breathing of the intubated patient with some pressure from the ventilator. This support aims at avoiding excessive inspiratory effort, while ensuring a certain degree of training of the patient's inspiratory muscle. Avoiding both minimal and excessive assistance is thus important for the optimal care of the intubated patient ensuring a lung and diaphragm protective ventilation with the goal to liberate the patient from the ventilator as soon as possible.

Recently pressure-muscle-index (PMI), an index of inspiratory effort easy to be measured on the ventilator screen, has been proposed to avoid excessive assistance in PSV. This will be the first prospective study testing the effects of setting pressure support based on PMI to avoid excessive assistance on patients recovering from acute lung injury (acute hypoxemic respiratory failure).

Conditions

• Acute Hypoxemic Respiratory Failure

Intervention / Treatment

• Other: Measuring Respiratory Mechanics
• Other: Randomized Pressure Support

Primary Outcome Measures

• Inspiratory Occlusion (60 minutes)
  To investigate the role of the inspiratory occlusion as a diagnostic tool to understand the patient's desired tidal volume and minute ventilation in Pressure Support Ventilation (PSV),
• Pressure Muscle Index (PMI) (60 minutes)
  To investigate the role of a PMI\>0 strategy to avoid over-assistance in Pressure Support Ventilation

Countries

Canada

Locations and Investigators

• St. Michael's Hospital, Toronto, Canada (Recruiting)
  • Laurent Brochard, MD

Study Officials

• Laurent Brochard (Principal Investigator) — Unity Health Toronto - St. Michael's Hospital