Dr Heise is Chief Scientific Officer and Chairman of the Board of Directors of the private research institute Profil in Neuss, Germany. Founded in 1999 by Dr Heise and Dr Lutz Heinemann, Profil became known as the premier source of solutions to the challenging early phase studies of experimental diabetes and obesity treatments often using sophisticated methodology like the glucose clamp technique in combination with isotope dilution, biopsies and/or indirect calorimetry.

Dr Heise has led numerous studies in people with type 1 or type 2 diabetes, obesity, pre-diabetes and insulin resistance. His research focus is the pharmacological properties of antidiabetic and weight-loss drugs, in particular novel insulin preparations and incretin-based therapies. In addition, his study team at Profil has gained outstanding reputation for the evaluation of medical devices.

Before establishing Profil, Dr Heise worked for more than 7 years at the Clinic for Nutrition and Metabolic Diseases at the Heinrich-Heine-University Düsseldorf (Head Prof Michael Berger). During this time, he was responsible for the diabetes and obesity outpatient clinics and took care of patients in structured teaching and treatment programs for type 1 and type 2 diabetes.

Dr Heise has published more than 250 scientific papers and reviews. He is a member of the Editorial Boards of Diabetes, Obesity and Metabolism, and Diabetes Technology & Therapeutics.