Journal Article Research Support, Non-U.S. Gov't Ppublish 10 citations
PubMed: 32424947 DOI: 10.1002/mrm.28314
Supporting measurements or more averages? How to quantify cerebral blood flow most reliably in 5 minutes by arterial spin labeling.
Magn Reson Med 84(5):2523-2536
Authors: Piet Bladt, Matthias J P van Osch, Patricia Clement, Eric Achten, Jan Sijbers, Arnold J den Dekker
Affiliations
- imec - Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium.
- Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
- Leiden Institute of Brain and Cognition, Leiden University, Leiden, The Netherlands.
- Department of Radiology and Nuclear Medicine, Ghent University, Ghent, Belgium.
Abstract
PURPOSE
To determine whether sacrificing part of the scan time of pseudo-continuous arterial spin labeling (PCASL) for measurement of the labeling efficiency and blood is beneficial in terms of CBF quantification reliability.
METHODS
In a simulation framework, 5-minute scan protocols with different scan time divisions between PCASL data acquisition and supporting measurements were evaluated in terms of CBF estimation variability across both noise and ground truth parameter realizations taken from the general population distribution. The entire simulation experiment was repeated for a single-post-labeling delay (PLD), multi-PLD, and free-lunch time-encoded (te-FL) PCASL acquisition strategy. Furthermore, a real data study was designed for preliminary validation.
RESULTS
For the considered population statistics, measuring the labeling efficiency and the blood proved beneficial in terms of CBF estimation variability for any distribution of the 5-minute scan time compared to only acquiring ASL data. Compared to single-PLD PCASL without support measurements as recommended in the consensus statement, a 26%, 33%, and 42% reduction in relative CBF estimation variability was found for optimal combinations of supporting measurements with single-PLD, free-lunch, and multi-PLD PCASL data acquisition, respectively. The benefit of taking the individual variation of blood into account was also demonstrated in the real data experiment.
CONCLUSIONS
Spending time to measure the labeling efficiency and the blood instead of acquiring more averages of the PCASL data proves to be advisable for robust CBF quantification in the general population.
MeSH
Research Design, Blood, Multiple Chronic Conditions, Lunch, Blood Circulation
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- Supporting measurements or more averages? How to quantify cerebral blood flow most reliably in 5 minutes by arterial spin labeling. Magn Reson Med, 2021
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- Test-retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease. Transl Stroke Res, 2022
- Multidelay ASL of the pediatric brain. Br J Radiol, 2022
- Measuring Quantitative Cerebral Blood Flow in Healthy Children: A Systematic Review of Neuroimaging Techniques. J Magn Reson Imaging, 2023
- Comparing single- and multi-post labeling delays for the measurements of resting cerebral and hippocampal blood flow for cerebrovascular testing in midlife adults. Front Physiol, 2024