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Journal Article Ppublish 102 citations

PubMed: 35178513 DOI: 10.1117/1.ap.3.4.044001

Review of bio-optical imaging systems with a high space-bandwidth product.

Adv Photonics 3(4)

Authors: Jongchan Park, David J Brady, Guoan Zheng, Lei Tian, Liang Gao

Affiliations

  • University of California, Department of Bioengineering, Los Angeles, California, United States.
  • University of Arizona, James C. Wyant College of Optical Sciences, Tucson, Arizona, United States.
  • University of Connecticut, Department of Biomedical Engineering, Storrs, Connecticut, United States.
  • University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut, United States.
  • Boston University, Department of Electrical and Computer Engineering, Boston, Massachusetts, United States.

Abstract

Optical imaging has served as a primary method to collect information about biosystems across scales-from functionalities of tissues to morphological structures of cells and even at biomolecular levels. However, to adequately characterize a complex biosystem, an imaging system with a number of resolvable points, referred to as a space-bandwidth product (SBP), in excess of one billion is typically needed. Since a gigapixel-scale far exceeds the capacity of current optical imagers, compromises must be made to obtain either a low spatial resolution or a narrow field-of-view (FOV). The problem originates from constituent refractive optics-the larger the aperture, the more challenging the correction of lens aberrations. Therefore, it is impractical for a conventional optical imaging system to achieve an SBP over hundreds of millions. To address this unmet need, a variety of high-SBP imagers have emerged over the past decade, enabling an unprecedented resolution and FOV beyond the limit of conventional optics. We provide a comprehensive survey of high-SBP imaging techniques, exploring their underlying principles and applications in bioimaging.

MeSH

Optical Imaging

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