System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Review Epublish 50 citations

PubMed: 35663580 DOI: 10.3389/fnagi.2022.827263

Neuroinflammation: A Possible Link Between Chronic Vascular Disorders and Neurodegenerative Diseases.

Front Aging Neurosci 14:827263

Authors: Emmanuel Moyse, Slavica Krantic, Nesrine Djellouli, Sébastien Roger, Denis Angoulvant, Camille Debacq, Victoire Leroy, Bertrand Fougere, Amal Aidoud

Affiliations

  • University of Tours, EA4245, Transplantation, Immunologie, Inflammation, Tours, France.
  • Centre de Recherche Saint-Antoine (CRSA), Immune System and Neuroinflammation Laboratory, Hôpital Saint-Antoine, Inserm U938, Sorbonne Université, Paris, France.
  • Department of Cardiology, Tours University Hospital, Tours, France.
  • Division of Geriatric Medicine, Tours University Hospital, Tours, France.
  • University of Tours, EA7505, Education, Ethics, Health, Tours, France.

Abstract

Various age-related diseases involve systemic inflammation, i.e. a stereotyped series of acute immune system responses, and aging itself is commonly associated with low-grade inflammation or inflamm'aging. Neuroinflammation is defined as inflammation-like processes inside the central nervous system, which this review discusses as a possible link between cardiovascular disease-related chronic inflammation and neurodegenerative diseases. To this aim, neuroinflammation mechanisms are first summarized, encompassing the cellular effectors and the molecular mediators. A comparative survey of the best-known physiological contexts of neuroinflammation (neurodegenerative diseases and transient ischemia) reveals some common features such as microglia activation. The recently published transcriptomic characterizations of microglia have pointed a marker core signature among neurodegenerative diseases, but also unraveled the discrepancies with neuroinflammations related with acute diseases of vascular origin. We next review the links between systemic inflammation and neuroinflammation, beginning with molecular features of respective pro-inflammatory cells, i.e. macrophages and microglia. Finally, we point out a gap of knowledge concerning the atherosclerosis-related neuroinflammation, which is for the most surprising given that atherosclerosis is established as a major risk factor for neurodegenerative diseases.

MeSH

Aging, Macrophages, Atherosclerosis, Neurodegenerative Diseases, Astrocytes, Microglia

Cited by