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Journal Article Review Epublish 34 citations

PubMed: 36570532 DOI: 10.3389/fnagi.2022.1077384

Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies.

Front Aging Neurosci 14:1077384

Authors: Dan Shan, Shaoyang Li, Ruichen Xu, Glen Nie, Yangyiran Xie, Junchu Han, Xiaoyi Gao, Yuandian Zheng, Zhen Xu, Zhihao Dai

Affiliations

  • Department of Biobehavioral Sciences, Columbia University, New York, NY, United States.
  • Faculty of Science, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
  • Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, United States.
  • Department of Biological Science, Northeastern University, Boston, MA, United States.
  • School of Medicine, Vanderbilt University, Nashville, TN, United States.
  • New York State Psychiatric Institute, Global Psychiatric Epidemiology Group, New York, NY, United States.
  • School of Medicine, Saint Louis University, St. Louis, MO, United States.
  • Minhang Crosspoint Academy at Shanghai Wenqi Middle School, Shanghai, China.
  • School of Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Ireland.

Abstract

Many people with coronavirus disease 2019 (COVID-19) report varying degrees of memory impairment. Neuroimaging techniques such as MRI and PET have been utilized to shed light on how COVID-19 affects brain function in humans, including memory dysfunction. In this PRISMA-based systematic review, we compared and summarized the current literature looking at the relationship between COVID-19-induced neuropathological changes by neuroimaging scans and memory symptoms experienced by patients who recovered from COVID-19. Overall, this review suggests a correlational trend between structural abnormalities (e.g., cortical atrophy and white matter hyperintensities) or functional abnormalities (e.g., hypometabolism) in a wide range of brain regions (particularly in the frontal, parietal and temporal regions) and memory impairments in COVID-19 survivors, although a causal relationship between them remains elusive in the absence of sufficient caution. Further longitudinal investigations, particularly controlled studies combined with correlational analyses, are needed to provide additional evidence.

MeSH

Brain, Memory, Neuroimaging, Covid-19

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