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Journal Article Review Ppublish 2 citations

PubMed: 40045458 DOI: 10.1002/ctm2.70253

Ferroptosis of T cell in inflammation and tumour immunity.

Clin Transl Med 15(3):e70253

Authors: Xueli Xia, Haisheng Wu, Yuxuan Chen, Huiyong Peng, Shengjun Wang

Affiliations

  • Department of Laboratory Medicine, Jiangsu Province Engineering Research Center for Precise Diagnosis and Treatment of Inflammatory Diseases, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
  • Department of Immunology, Jiangsu University School of Medicine, Zhenjiang, China.
  • Qinghai Provincial Institute of Endemic Disease Prevention and Control, Xining, China.
  • Department of Laboratory Medicine, Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
  • Department of Laboratory Medicine, Jiangsu Province Engineering Research Center for Precise Diagnosis and Treatment of Inflammatory Diseases, Affiliated Hospital of Jiangsu University, Zhenjiang, China. Department of Immunology, Jiangsu University School of Medicine, Zhenjiang, China.

Abstract

Ferroptosis is an innovative concept defined as a distinct programmed cell death mode regulated by iron-dependent lipid peroxidation accumulation. This process is governed by numerous energy metabolites such as fatty acids, amino acids and glucose, as well as iron homeostasis. In recent years, increasing studies have been devoted to the crucial effects of ferroptosis in immune cells during the pathogenesis of diseases such as infections, tumours and autoimmune disorders. This review summarises the latest advancements in T-cell ferroptosis, addresses the key components and mechanism of ferroptosis in T cells during inflammatory conditions and tumour progression, and highlights the potential target for treating related diseases. KEY POINTS: Ferroptosis-related mechanisms significantly affect the biology of CD4 T-cell subsets and are further involved in inflammatory diseases. Crosstalk between CD8 T cells and tumour cells induces ferroptosis in the tumour microenvironment. Glutathione peroxidase 4 loss promotes regulatory T-cell ferroptosis to enhance anti-tumour immunity.

MeSH

Cells, Amino Acids, Ferroptosis, Clinical Medicine, Immunity, T-Lymphocytes

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