Nicola Fazio

Oncology — Fondazione IRCCS Istituto Nazionale dei Tumori, Italy

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Oncology

Subspecialties: Endocrinology - Surgery - Hematology

Full career Last 3 years

Main Topics

Publications and Clinical Studies

Publications Clinical Studies

Short Biography

Nicola Fazio graduated at the University of L’Aquila, Italy, Faculty of Medicine and Surgery, in 1988, where he also specialised in Internal Medicine in 1993.

In 2002 he specialized in Medical Oncology at University of Milan.

In 2013 he gained his Ph.D. in Digestive Oncology at the University of Rome “La Sapienza”.

Fazio is currently Director of the Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumours and Director of the Programme in Digestive and Neuroendocrine Tumours at the European Institute of Oncology, in Milan, Italy, where he has been working since 1995.

Since 2015 he is head of the IEO ENETS Centre of Excellence for GEP NENs and lung NETs.

From 2013 to 2019 he served as coordinator of the Italian (AIOM/ITANET) neuroendocrine neoplasms guidelines.

Fazio is full member of American Society of Clinical Oncology (ASCO) since 2000 and full member of the European Society for Medical Oncology (ESMO) since 2002. He has

been serving as ESMO Faculty Coordinator for Neuroendocrine, Endocrine and

CUP for the period 2016-2019 and he is currently member of the NET end endocrine tumors ESMO faculty. He served as chair of the ESMO NEN Preceptorship in 2017, 2018, 2019 and 2021 and chair of the ESMO NEN Advanced Course in 2019 and 2021.

Since 2015 he has been member of the European Neuroendocrine Tumour Society (ENETS) Advisory Board and he served as Advisory Board Speaker for the period 2018-2020. Since 2020 he is member of ENETS executive committee. Between 2021 and 2024 he served as chair of the ENETS certification of centers of excellence and co-chair of the academic database research activity. In 2024 he has been nominated ENETS President Elect; he will take over the active presidency in March 2026.

His research has focused on multidisciplinary and translational clinical research in neuroendocrine neoplasms and gastrointestinal cancers.

He has participated as invited speaker in several national and international meetings and has co-authored more than 300 publications in peer-reviewed journals.


Organizations

Source: Pubmed

European Institute of Oncology

Publications Synthesis

Source: Pubmed

Number : 471

Citations

Citations: 14 097 1st author: 50 Last author: 101 Unique author: 5

Main journals

Ann Oncol 52
J Clin Oncol 43
Neuroendocrinology 34
Cancer Treat Rev 24
Eur J Cancer 17

Best Journals

Ann Oncol 20
J Clin Oncol 16
Lancet Oncol 4

Breakdown by type

Latest Publications

5 most recent indexed articles

Source: Pubmed

Title Journal Year Citations
First-line zolbetuximab plus mFOLFOX6 and nivolumab in unresectable CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial.
safety, esophagogastric junction, neoplasms, adenocarcinoma, nivolumab, therapeutics
Nat Med Top journal20260
Real-world presentation and outcomes of gastroenteropancreatic neuroendocrine neoplasms in Italy: findings from the nationwide Itanet prospective database.
neoplasms, therapeutics
Lancet Reg Health Eur20260
Blood-based circulating tumour DNA (ctDNA) tests for colorectal cancer screening: Systematic review and meta-analysis of diagnostic accuracy.
research design, blood, neoplasms, colorectal neoplasms, wounds and injuries, dna, liquid biopsy
Crit Rev Oncol Hematol20260
Streptozotocin revisited: Pharmacological determinants supporting new scheduling strategies in neuroendocrine tumours.
biomarkers, fluorouracil, streptozocin, therapeutics
Cancer Treat Rev20260
Diagnostic and Therapeutic Challenges Related to HER2 Heterogeneity in Gastric Cancer: Bridging Molecular Pathology and Clinical Decision-Making.
research design, clinical decision-making, neoplasms, pathology, pathology, molecular, decision making, biopsy, therapeutics, stomach neoplasms
Int J Mol Sci20260

Clinical Studies 21

Source: ClinicalTrials

Synthesis

Principal Investigator: 3 Study Chair: 2

By phase:

Phase 2 10
N/A 6
Phase 3 5

By status:

Completed 10
Recruiting 6
Active not recruiting 2
Unknown 2
Not yet recruiting 1

By type:

Interventional 15
Observational 6

By Monocentric/Multicentric:

monocentric 6
multicentric2to4 0
multicentric5to9 2
multicentricup10 13

Main Topics

Digestive System Diseases 8
Endocrine System Diseases 4
Hemic and Lymphatic Diseases 2

Ongoing Clinical Trials

5 ongoing trials started since 2021, where this expert is an investigator

Source: ClinicalTrials

Study Phase Status Start
Institution of an Italian Multicenter Database of Patients With Multiple Endocrine Neoplasia Type 1 (MENNET1 Database)
NCT06790251 — endocrinology, quality of life, incidence, data collection, multiple endocrine neoplasia type 1, neoplasms, endocrine gland neoplasms, multiple endocrine neoplasia, endocrine glands, prevalence, diagnosis, therapeutics, male
N/ANot yet recruiting2025
EpigenOMic Determinants of the Neuroendocrine Phenotype As Biomarkers for Neuroendocrine Neoplasms
NCT06785597 — epigenomics, neoplasms, phenotype, biopsy, biomarkers, neuroendocrine tumors, diagnosis, liquid biopsy
N/ARecruiting2024
Efficacy and Safety of Radiotherapy Compared to Everolimus in Somatostatin Receptor Positive Neuroendocrine Tumors of the Lung and Thymus
NCT05918302 — radiotherapy, lung, somatostatin, safety, thymus neoplasms, neoplasms, everolimus, neuroendocrine tumors, receptors, somatostatin, patient reported outcome measures, thymus gland, therapeutics, receptors, peptide, octreotide
Phase 3Recruiting2023
Metronomic Temozolomide in Unfit NENs Patients Metronomic Temozolomide in Unfit Patients With Advanced Neuroendocrine Neoplasms (NENs) MeTe Study
NCT05554003 — temozolomide, neoplasms, drug therapy, capsules, neuroendocrine tumors, diagnosis, therapeutics, frailty, chemotherapy
Phase 2Recruiting2022
68Ga DOTATOC Radio Guided Surgery With Probe in GEP NET
NCT05448157 — pancreatic neoplasms, lymph nodes, neoplasms, pancreas, neoplasm metastasis, lymph, neuroendocrine tumors, tissues, carcinoid tumor
N/AActive not recruiting2022

LeadR Networks

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Source: Pubmed Source: ClinicalTrials