Abstract

BACKGROUND

Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks.

OBJECTIVE

This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed.

MATERIALS AND METHODS

An electronic literature search was conducted by authors up to October 2019. Original articles were selected.

RESULTS

CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models.

CONCLUSION

The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.

MeSH

Chronic Pain, Pain, Chlorogenic Acid, Antioxidants, Neuropharmacology

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