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Journal Article Review Epublish 104 citations

PubMed: 35011874 DOI: 10.3390/jcm11010125

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology.

J Clin Med 11(1)

Authors: Ridha I S Alnuwaysir, Martijn F Hoes, Dirk J van Veldhuisen, Peter van der Meer, Niels Grote Beverborg

Affiliations

  • Department of Cardiology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

Abstract

Iron is an essential micronutrient for a myriad of physiological processes in the body beyond erythropoiesis. Iron deficiency (ID) is a common comorbidity in patients with heart failure (HF), with a prevalence reaching up to 59% even in non-anaemic patients. ID impairs exercise capacity, reduces the quality of life, increases hospitalisation rate and mortality risk regardless of anaemia. Intravenously correcting ID has emerged as a promising treatment in HF as it has been shown to alleviate symptoms, improve quality of life and exercise capacity and reduce hospitalisations. However, the pathophysiology of ID in HF remains poorly characterised. Recognition of ID in HF triggered more research with the aim to explain how correcting ID improves HF status as well as the underlying causes of ID in the first place. In the past few years, significant progress has been made in understanding iron homeostasis by characterising the role of the iron-regulating hormone hepcidin, the effects of ID on skeletal and cardiac myocytes, kidneys and the immune system. In this review, we summarise the current knowledge and recent advances in the pathophysiology of ID in heart failure, the deleterious systemic and cellular consequences of ID.

MeSH

Heart Failure, Exercise, Quality Of Life, Id, Iron Deficiencies

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