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Publications

Journal Article Review Epublish 36 citations

PubMed: 36430343 DOI: 10.3390/ijms232213862

Nanoparticles for Antimicrobial Agents Delivery-An Up-to-Date Review.

Int J Mol Sci 23(22)

Authors: Doina-Antonia Mercan, Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu

Affiliations

  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.
  • Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.
  • Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.

Abstract

Infectious diseases constitute an increasing threat to public health and medical systems worldwide. Particularly, the emergence of multidrug-resistant pathogens has left the pharmaceutical arsenal unarmed to fight against such severe microbial infections. Thus, the context has called for a paradigm shift in managing bacterial, fungal, viral, and parasitic infections, leading to the collision of medicine with nanotechnology. As a result, renewed research interest has been noted in utilizing various nanoparticles as drug delivery vehicles, aiming to overcome the limitations of current treatment options. In more detail, numerous studies have loaded natural and synthetic antimicrobial agents into different inorganic, lipid, and polymeric-based nanomaterials and tested them against clinically relevant pathogens. In this respect, this paper reviews the most recently reported successfully fabricated nanoformulations that demonstrated a great potential against bacteria, fungi, viruses, and parasites of interest for human medicine.

MeSH

Nanoparticles, Pharmaceutical Preparations, Drug Delivery Systems, Bacteria, Infections

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