Journal Article Review Research Support, N.I.H., Extramural Ppublish 16 citations
PubMed: 37409532 DOI: 10.1161/ATVBAHA.122.318247
Sex-Specific Differences in Lipoprotein Production and Clearance.
Arterioscler Thromb Vasc Biol 43(9):1617-1625
Authors: Donna M Conlon, Francine K Welty, Gissette Reyes-Soffer, Jaume Amengual
Affiliations
- Department of Medicine, University of Pennsylvania (D.M.C.).
- Division of Cardiology, Beth Israel Deaconess Medical Center (F.K.W.).
- Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons (G.R.-S.).
- Department of Food Science and Human Nutrition and Division of Nutritional Sciences. University of Illinois Urbana Champaign (J.A.).
Abstract
Therapeutic approaches to reduce atherogenic lipid and lipoprotein levels remain the most effective and assessable strategies to prevent and treat cardiovascular disease. The discovery of novel research targets linked to pathways associated with cardiovascular disease development has enhanced our ability to decrease disease burden; however, residual cardiovascular disease risks remain. Advancements in genetics and personalized medicine are essential to understand some of the factors driving residual risk. Biological sex is among the most relevant factors affecting plasma lipid and lipoprotein profiles, playing a pivotal role in the development of cardiovascular disease. This minireview summarizes the most recent preclinical and clinical studies covering the effect of sex on plasma lipid and lipoprotein levels. We highlight the recent advances in the mechanisms regulating hepatic lipoprotein production and clearance as potential drivers of disease presentation. We focus on using sex as a biological variable in studying circulating lipid and lipoprotein levels.
MeSH
Lipoproteins, Cardiovascular Diseases, Arteriosclerosis, Vascular Diseases, Sex, Atherosclerosis, Thrombosis, Triglycerides, Apolipoproteins, Plasma
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