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Publications

Journal Article Review Epublish 29 citations

PubMed: 38356588 DOI: 10.1016/j.heliyon.2024.e25521

A critical review on metal-organic frameworks (MOFs) based nanomaterials for biomedical applications: Designing, recent trends, challenges, and prospects.

Heliyon 10(3):e25521

Authors: Samreen Sadiq, Shoaib Khan, Iltaf Khan, Aftab Khan, Muhammad Humayun, Ping Wu, Muhammad Usman, Abbas Khan, Amal Faleh Alanazi, Mohamed Bououdina

Affiliations

  • School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
  • College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin, 150030, China.
  • Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management (IRC-HTCM), King Fahd University of Petroleum and Minerals, Dhahran, 31261, Saudi Arabia.
  • Department of Physics, School of Science, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 212100, China.
  • Energy, Water and Environment Lab, College of Humanities and Sciences, Prince Sultan University, Riyadh, 11586, Saudi Arabia.
  • Department of Chemistry, Abdul Wali Khan University Mardan, 23200, Pakistan.

Abstract

Nanomaterials (NMs) have garnered significant attention in recent decades due to their versatile applications in a wide range of fields. Thanks to their tiny size, enhanced surface modifications, impressive volume-to-surface area ratio, magnetic properties, and customized optical dispersion. NMs experienced an incredible upsurge in biomedical applications including diagnostics, therapeutics, and drug delivery. This minireview will focus on notable examples of NMs that tackle important issues, demonstrating various aspects such as their design, synthesis, morphology, classification, and use in cutting-edge applications. Furthermore, we have classified and outlined the distinctive characteristics of the advanced NMs as nanoscale particles and hybrid NMs. Meanwhile, we emphasize the incredible potential of metal-organic frameworks (MOFs), a highly versatile group of NMs. These MOFs have gained recognition as promising candidates for a wide range of bio-applications, including bioimaging, biosensing, antiviral therapy, anticancer therapy, nanomedicines, theranostics, immunotherapy, photodynamic therapy, photothermal therapy, gene therapy, and drug delivery. Although advanced NMs have shown great potential in the biomedical field, their use in clinical applications is still limited by issues such as stability, cytotoxicity, biocompatibility, and health concerns. This review article provides a thorough analysis offering valuable insights for researchers investigating to explore new design, development, and expansion opportunities. Remarkably, we ponder the prospects of NMs and nanocomposites in conjunction with current technology.

MeSH

Therapeutics, Nanostructures, Metal-Organic Frameworks

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