Abstract

Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics techniques has been addressed to every level of application, from the detection of mutations, methods of diagnosis or monitoring, drug target discovery, and vaccine generation, to the basic definition of the pathophysiological processes and the biochemical mechanisms behind the infection and spread of SARS-CoV-2. Thus, the term COVIDomics wants to include those efforts provided by omics-scale investigations with application to the current COVID-19 research. This review summarizes the diverse pieces of knowledge acquired with the application of COVIDomics techniques, with the main focus on proteomics and metabolomics studies, in order to capture a common signature in terms of proteins, metabolites, and pathways dysregulated in COVID-19 disease. Exploring the multiomics perspective and the concurrent data integration may provide new suitable therapeutic solutions to combat the COVID-19 pandemic.

MeSH

Infections, Disease Progression, Research, Proteomics, Metabolomics, Pandemics, Covid-19, Sars-Cov-2

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• Sex differences in the human metabolome. Biol Sex Differ, 2022
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• Immunometabolic chaos in septic shock. J Leukoc Biol, 2025
• Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection. Front Immunol, 2022
• Quantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome. Metabolomics, 2023
• Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity. Hum Vaccin Immunother, 2023
• Comprehensive clinical and metabolomics profiling of COVID-19 Mexican patients across three epidemiological waves. Front Mol Biosci, 2025
• Development of a proteomic signature associated with severe disease for patients with COVID-19 using data from 5 multicenter, randomized, controlled, and prospective studies. Sci Rep, 2023
• Circulating Peptidome Is Strongly Altered in COVID-19 Patients. Int J Environ Res Public Health, 2023
• Mapping the knowledge of omics in myocardial infarction: A scientometric analysis in R Studio, VOSviewer, Citespace, and SciMAT. Medicine (Baltimore), 2025
• Can Biomarkers Predict Kidney Function Recovery and Mortality in Patients with Critical COVID-19 and Acute Kidney Injury? Diagnostics (Basel), 2025
• Dissecting inflammation in the immunemetabolomic era. Cell Mol Life Sci, 2025
• Plasma Proteomic Variables Related to COVID-19 Severity: An Untargeted nLC-MS/MS Investigation. Int J Mol Sci, 2023
• The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy. Front Immunol, 2023
• Nucleotide, Phospholipid, and Kynurenine Metabolites Are Robustly Associated with COVID-19 Severity and Time of Plasma Sample Collection in a Prospective Cohort Study. Int J Mol Sci, 2024